Table 2 Multivariate survival analysis (Cox regression model) of variables (with and without COL11A1) predicting outcome in terms of ipsilateral local all recurrences (A) and invasive recurrences (B) in patients treated by breast conserving surgery in pure DCIS
From: Collagen (XI) alpha-1 chain is an independent prognostic factor in breast ductal carcinoma in situ
Conventional clinicopathological parameters associated with high-risk DCIS | ||||
|---|---|---|---|---|
Parameters | Hazard ratio (HR) | 95% confidence interval (CI) | p value | |
Lower | Upper | |||
A) All recurrences | ||||
Patient Age | 0.4 | 0.2 | 0.8 | 0.006 |
DCIS presentation | 1.5 | 0.9 | 2.4 | 0.111 |
DCIS size | 1.5 | 1.1 | 2.1 | 0.040 |
DCIS nuclear Grade | 1.9 | 1.3 | 2.7 | 0.001 |
Comedo necrosis | 0.6 | 0.4 | 0.9 | 0.049 |
Margin status | 0.8 | 0.7 | 0.9 | 0.004 |
COL11A1 and other clinicopathological parameters associated with high-risk DCIS | ||||
High stromal COL11A1 expression | 13.2 | 6.9 | 25.4 | < 0.0001 |
Patient Age | 0.6 | 0.3 | 1.4 | 0.261 |
DCIS presentation | 1.9 | 0.9 | 3.9 | 0.084 |
DCIS size | 1.1 | 0.7 | 1.9 | 0.609 |
DCIS nuclear Grade | 1.6 | 0.9 | 3.1 | 0.123 |
Comedo necrosis | 0.5 | 0.2 | 1.2 | 0.120 |
Margin status | 1.0 | 0.9 | 1.1 | 0.728 |
B) Invasive recurrence | ||||
Conventional clinicopathological parameters associated with high-risk DCIS | ||||
Patient Age | 0.5 | 0.2 | 1.3 | 0.156 |
DCIS presentation | 1.4 | 0.8 | 2.6 | 0.245 |
DCIS size | 1.8 | 1.1 | 2.4 | 0.013 |
DCIS nuclear Grade | 1.9 | 1.1 | 3.0 | 0.013 |
Comedo necrosis | 0.7 | 0.4 | 1.3 | 0.274 |
Margin status | 0.9 | 0.8 | 1.1 | 0.075 |
COL11A1 and other clinicopathological parameters associated with high-risk DCIS | ||||
High stromal COL11A1 expression | 11.2 | 4.9 | 25.8 | < 0.0001 |
Patient Age | 0.9 | 0.3 | 3.3 | 0.974 |
DCIS presentation | 2.0 | 0.8 | 5.2 | 0.156 |
DCIS size | 1.5 | 0.7 | 2.9 | 0.258 |
DCIS nuclear Grade | 1.9 | 0.8 | 4.4 | 0.119 |
Comedo necrosis | 0.5 | 0.2 | 1.3 | 0.159 |
Margin status | 1.1 | 0.9 | 1.2 | 0.386 |
