Table 1 H3K27me3 and H3K27me2 IHC in selected tumors

From: Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss

Tumor type

H3K27me3 loss

H3K27me2 loss

Malignant peripheral nerve sheath tumor, total (N = 72) Sporadic (N = 36) NF1 (N = 30) Radiation (N = 6)

34 (47%) 12 (33%) 17 (57%) 5 (83%)

33 (46%) 12 (33%) 17 (57%) 5 (83%)

H3K27M-mutant glioma (N = 7)

7 (100%)

0 (0%)

Ependymoma (N = 43)

21 (48.8%)

0 (0%)

Merkel cell carcinoma (N = 10)

9 (90%)

0 (0%)

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