Table 3 Collective H3K27me3 IHC results from prior malignant peripheral nerve sheath tumor studies

From: Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss

Study

Sporadic

Syndromic

Radiation

Reference

Asano et al.

14/20 (70%)

16/34 (47%)

–

13

Cleven et al.

17/54 (31%)

33/80 (41%)

–

10

Le Guellec et al.

38/53 (72%)

46/65 (71%)

4/4 (100%)

12

Otsuka et al.

18/50 (36%)

19/43 (44%)

–

11

Pekmezci et al.

4/13 (31%)

13/26 (50%)

–

14

Prieto-Granada et al.

16/18 (89%)

15/33 (45%)

11/12 (92%)

8

Schaefer et al.

34/70 (49%)

7/10 (70%)

10/10 (100%)

9

This study

12/36 (33%)

17/30 (57%)

5/6 (83%)

 

total

153/314 (49%)

166/321 (52%)

30/32 (94%)

 
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