Fig. 1 | Modern Pathology

Fig. 1

From: Colorectal carcinoma with double somatic mismatch repair gene inactivation: clinical and pathological characteristics and response to immune checkpoint blockade

Fig. 1

Histological patterns and DNA mismatch repair protein immunohistochemistry of colorectal carcinomas with double somatic mismatch repair gene mutation/alteration. Case #2 (a–d) exhibits a medullary pattern with tumor cells growing in sheets and nests, and containing easily discernible tumor-infiltrating-lymphocytes (a). By immunohistochemistry, this tumor shows loss of MSH2 (b) and MSH6 (c), and retained MLH1 (not illustrated) and PMS2 (d). Case #6 (E-H) exhibits well formed glands with only very mildly elevated tumor-infiltrating-lymphocytes (e). By immunohistochemistry, this tumor shows loss of MSH2 (f) and MSH6 (g), and retained MLH1 (not illustrated) and PMS2 (h). Case #7 (I-L) exhibits a solid growth with high grade cytology and inconspicuous tumor-infiltrating-lymphocytes (i). By immunohistochemistry, this tumor shows retained MSH2 (j), loss of MSH6 (k), and retained MLH1 (not illustrated) and PMS2 (L)

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