Fig. 2 | Modern Pathology

Fig. 2

From: Histological differences in cancer cells, stroma, and luminal spaces strongly correlate with in vivo MRI-detectability of prostate cancer

Fig. 2

Representative example of semi-automated analysis of histological images. a, b Immunohistochemical staining for cytokeratin AE1/AE3 highlighting cancer cells in (a) an MRI-detectable cancer and (b) an MRI-undetectable cancer, both of which show cribriform predominant growth. c, d Tissue components in (c) an MRI-detectable cancer and (d) an MRI-undetectable tumor are segmented into stroma (blue), luminal spaces (white), and cancer cells. Note a relatively higher area fraction of cancer cells and lower area fraction of stroma and luminal space in an MRI-detectable cancer as compared with an MRI-undetectable cancer. Immunoperoxidase stain, original magnification ×100

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