Fig. 2
From: GLI1-amplifications expand the spectrum of soft tissue neoplasms defined by GLI1 gene fusions
Morphologic and immunohistochemical spectrum of GLI1-amplified tumors. A–C Case 6 (39/M, neck) showed a biphasic histology with the epithelioid nested growth (A) in abrupt transition with the spindle cell component arranged in short fascicles (B); immunohistochemical stain for SMA (C) showing diffuse positivity. D–F Case 7 (51/F, back) showing (D) bland epithelioid cells arranged in single files in a collagenous stroma. Other areas showed more solid growth with increased atypia and mitotic activity (E). Immunohistochemical stain for S100 (F) showing patchy strong positivity. G–I Images from Case 8 (54/F, elbow) showing distinctive multinodular growth (G), which on high power reveals a tight nested growth of uniform epithelioid cells (H). Immunohistochemical stain for CDK4 (I) showing strong and diffuse positivity
