Fig. 3
From: GLI1-amplifications expand the spectrum of soft tissue neoplasms defined by GLI1 gene fusions
Morphologic and immunohistochemical spectrum of GLI1-amplified tumors. Case 4 (23/F, thigh) showing tumor lobules with cribriform or distinctive rosette-like pattern, separated by a fibrotic stroma (A), with high power also showing cord-like and trabecular pattern (B); C–D Case 5 (26/F, lung) showing tumor cells in a trabecular pattern with intervening sinusoidal pattern. Immunohistochemical stain for CD56 (D) showing positivity. E– I Case 10 (65/M, tongue) showed a compact growth, with vague nested growth of epithelioid cells separated by fibrotic stroma; tumor cells were uniform and showed clear cytoplasm (E). Diffuse positivity for MDM2 (F), CDK4 (G) and STAT6 (H) immunohistochemical stains was noted. FISH showed GLI1 gene (green-centromeric, red-telomeric) amplification (arrows) (I)
