Fig. 4
From: GLI1-amplifications expand the spectrum of soft tissue neoplasms defined by GLI1 gene fusions
GLI1 mRNA upregulation in tumors with GLI1 genetic abnormalities. A high GLI1 mRNA overexpression was present in cases with both GLI1 amplifications (cases’ 3 and 8) and GLI1 fusions (3 cases) [7]. One dedifferentiated liposarcoma with GLI1/CDK4/MDM2 co-amplification showed a lower level of upregulation. In contrast 2 dedifferentiated liposarcomas with MDM2/CDK4 amplification and other sarcoma types showed no increased GLI1 mRNA levels. Higher levels of STAT6 and HMGA2 expression were noted in cases with GLI1 amplification suggesting their co-amplification gene status; in contrast to tumors with GLI1 fusions. The genomic positions and relationship of the genes located on the 12q13-15 locus (lower panel)
