Table 2 Multivariate survival analysis (Cox regression model) of variables predicting outcome in terms of ipsilateral local recurrence (either all recurrences (a), or invasive recurrences (b)) in DCIS patients treated by breast-conserving surgery
Parameters | Hazard ratio (HR) | 95% confidence interval (CI) | p value | |
|---|---|---|---|---|
Lower | Upper | |||
(a) All recurrences | ||||
Conventional clinicopathological parameters associated with high-risk DCIS | ||||
Patient age | 0.4 | 0.2 | 0.8 | 0.006 |
DCIS presentation | 1.5 | 0.9 | 2.4 | 0.111 |
DCIS size | 1.5 | 1.1 | 2.1 | 0.040 |
DCIS nuclear grade | 1.9 | 1.3 | 2.7 | 0.001 |
Comedo necrosis | 0.6 | 0.4 | 0.9 | 0.049 |
Margin status | 0.8 | 0.7 | 0.9 | 0.004 |
Collagen prognostic index and other clinicopathological parameters associated with high-risk DCIS | ||||
Collagen prognostic index | 2.3 | 1.3 | 4.2 | 0.005 |
Patient age | 0.5 | 0.2 | 1.1 | 0.072 |
DCIS presentation | 2.1 | 0.9 | 4.3 | 0.052 |
DCIS size | 0.9 | 0.5 | 1.6 | 0.760 |
DCIS nuclear grade | 1.1 | 0.5 | 1.9 | 0.994 |
Comedo necrosis | 0.8 | 0.4 | 1.6 | 0.559 |
Margin status | 0.9 | 0.8 | 1.1 | 0.236 |
(b) Invasive recurrence | ||||
Conventional clinicopathological parameters associated with high-risk DCIS | ||||
Patient age | 0.5 | 0.2 | 1.3 | 0.156 |
DCIS presentation | 1.4 | 0.8 | 2.6 | 0.245 |
DCIS size | 1.8 | 1.1 | 2.4 | 0.013 |
DCIS nuclear grade | 1.9 | 1.1 | 3.0 | 0.013 |
Comedo necrosis | 0.7 | 0.4 | 1.3 | 0.274 |
Margin status | 0.9 | 0.8 | 1.1 | 0.075 |
Collagen prognostic index and other clinicopathological parameters associated with high-risk DCIS | ||||
Collagen prognostic index | 3.4 | 1.5 | 7.6 | 0.003 |
Patient age | 1.2 | 0.4 | 3.7 | 0.697 |
DCIS presentation | 3.0 | 1.2 | 7.9 | 0.025 |
DCIS size | 1.3 | 0.7 | 2.7 | 0.412 |
DCIS nuclear grade | 0.9 | 0.4 | 2.3 | 0.909 |
Comedo necrosis | 0.9 | 0.4 | 2.1 | 0.786 |
Margin status | 0.9 | 0.8 | 1.1 | 0.838 |
