Fig. 1 | Modern Pathology

Fig. 1

From: Quantitative next-generation sequencing-based analysis indicates progressive accumulation of microsatellite instability between atypical hyperplasia/endometrial intraepithelial neoplasia and paired endometrioid endometrial carcinoma

Fig. 1

Paired atypical hyperplasia/endometrial intraepithelial neoplasia and carcinoma show concordant mismatch repair protein expression profiles in Case 7. The atypical hyperplasia/endometrial intraepithelial neoplasia focus a shows complete loss of MLH1 (not shown) and PMS2 (b), with retention of MSH2 (not shown) and MSH6 (c). The carcinoma component (d) shows an identical pattern, with loss of MLH1 (not shown) and PMS2 (e) but retention of MSH2 (not shown) and MSH6 (f). (a, d: hematoxylin and eosin, original magnification 100 × ; b, c, e, f: immunohistochemical stains with brown diaminobenzidine peroxidase-based detection, original magnification ×100 )

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