Fig. 5 | Modern Pathology

Fig. 5

From: Quantitative next-generation sequencing-based analysis indicates progressive accumulation of microsatellite instability between atypical hyperplasia/endometrial intraepithelial neoplasia and paired endometrioid endometrial carcinoma

Fig. 5

Clonally related atypical hyperplasia/endometrial intraepithelial neoplasia and carcinoma pairs showed discordant mismatch repair protein expression profiles in few cases. In Case 5, the atypical hyperplasia/endometrial intraepithelial neoplasia focus (a) shows retention of PMS2 (b) as well as MLH1, MSH2, and MSH6 (not shown). The paired carcinoma (c) shows loss of MLH1 (not shown) and PMS2 (d) but retained expression of MSH2 and MSH6 (not shown). (a, c: hematoxylin and eosin, original magnification ×100; b, d immunohistochemical stains with brown diaminobenzidine peroxidase-based detection, original magnification ×100)

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