Table 4 Accuracy of markers in combination to predict a lower gastrointestinal primary
GI vs Ov | CRC vs Ov | App vs Ov | ||||||
|---|---|---|---|---|---|---|---|---|
Rank | Markers (N) | Marker combination assessed | ROC | Accuracy | ROC | Accuracy | ROC | Accuracy |
1 | 5 | CK7 3-tier, SATB2 3-tier, CDX2 3-tier, PAX8 3-tier, CK20 3-tier | 0.981 | 95.3 | 0.988 | 96.0 | 0.976 | 94.7 |
2 | 4 | CK7 3-tier, SATB2 3-tier, CDX2 3-tier, PAX8 3-tier | 0.978 | 95.8 | 0.986 | 95.7 | 0.973 | 94.7 |
3 | 3 | CK7 3-tier, SATB2 3-tier, PAX8 3-tier | 0.978 | 95.6 | 0.986 | 95.7 | 0.969 | 93.9 |
4 | 3 | CK7 3-tier, SATB2 3-tier, CDX2 3-tier | 0.976 | 95.6 | 0.986 | 95.7 | 0.966 | 93.5 |
5 | 2 | CK7 3-tier, SATB2 3-tier | 0.973 | 95.3 | 0.984 | 95.3 | 0.957 | 93.5 |
6 | 5 | SATB2 present, CK7 absent, PAX8 absent, CDX2 present, CK20 present | 0.972 | 95.3 | 0.983 | 94.6 | 0.96 | 93.1 |
7 | 4 | SATB2 present, CK7 absent, PAX8 absent, CDX2 present | 0.972 | 95.1 | 0.982 | 96.0 | 0.959 | 92.0 |
8 | 3 | SATB2 present, CK7 absent, PAX8 absent | 0.97 | 94.3 | 0.981 | 95.0 | 0.957 | 91.6 |
9 | 3 | CK7 3-tier, CDX2 3-tier, CK20 3-tier | 0.97 | 93.2 | 0.98 | 95.0 | 0.962 | 91.6 |
10 | 2 | SATB2 present, CK7 absent | 0.963 | 93.5 | 0.979 | 93.9 | 0.945 | 90.5 |
11 | 2 | CK7 3-tier, CK20 3-tier | 0.956 | 92.2 | 0.968 | 93.9 | 0.939 | 90.5 |
12 | 2 | CK7 nondiffuse, SATB2 present | 0.953 | 91.7 | 0.963 | 93.2 | 0.942 | 89.7 |
13 | 3 | CK7 absent, CDX2 present, CK20 present (clinical standard) | 0.922 | 87.5 | 0.954 | 93.9 | 0.886 | 86.6 |
