Table 5 OTTA expansion cohort SATB2 and PAX8 expression by histotype

From: A combination of the immunohistochemical markers CK7 and SATB2 is highly sensitive and specific for distinguishing primary ovarian mucinous tumors from colorectal and appendiceal metastases

Histotype

 

SATB2

PAX8

SATB2/PAX8

 

Total

Absent, n (%)

Focal, n (%)

Diffuse, n (%)

absent, n (%)

Focal, n (%)

Diffuse, n (%)

SATB2-/PAX8 + n (%)

SATB2-/PAX8- n (%)

SATB2 + /PAX8 + n (%)

SATB2 + /PAX8- n (%)

MC

159

137 (86%)

11 (7%)

11 (7%)

97 (61%)

40 (25%)

22 (14%)

59 (37%)

78 (49%)

3 (2%)

19 (12%)

MBOT

46

44 (96%)

0 (0%)

2 (4%)

23 (50%)

17 (37%)

6 (13%)

23 (50%)

21 (46%)

0 (0%)

2 (4%)

EC

515

439 (85%)

67 (13%)

9 (2%)

92 (18%)

148 (29%)

275 (53%)

364 (71%)

75 (15%)

59 (11%)

17 (3%)

CCC

386

371 (96%)

12 (3%)

3 (1%)

21 (5%)

29 (8%)

336 (87%)

351 (91%)

20 (5%)

14 (4%)

1 (0%)

HGSC

1698

1623 (96%)

69 (4%)

6 (0%)

80 (5%)

156 (9%)

1462 (86%)

1553 (91%)

70 (4%)

65 (4%)

10 (1%)

LGSC

72

67 (93%)

5 (7%)

0 (0%)

9 (13%)

4 (6%)

59 (82%)

58 (81%)

9 (13%)

5 (7%)

0 (0%)

  1. MC Mucinous carcinoma, MBOT Mucinous borderline ovarian tumor, EC Endometrioid carcinoma, CCC Clear cell carcinoma, HGSC High grade serous carcinoma, LGSC Low-grade serous carcinoma