Fig. 2
Hybrid oncocytic/chromophobe renal tumors display low mutational frequency and limited DNA copy number alterations. a Somatic mutations in hybrid oncocytic/chromophobe renal tumor samples, showing the four mutated genes and lack of mutations in the commonly mutated renal cell carcinoma driver genes. b Copy number alterations in hybrid oncocytic/chromophobe renal tumor. Red corresponds to a gain, light blue corresponds to a partial loss of a copy of one chromosomal arm, blue corresponds to complete loss of a chromosomal arm, and pink on chromosome Y indicates female sex. Each column represents the same sample for a and b with bold borders representing two samples from the same patient. c Copy number log-ratio (logR) and B allele frequency (BAF) plots obtained by targeted sequencing analysis of tumor and normal pairs from a patient with losses on chromosomes 1 and Y and a patient without large-scale copy number alterations d
