Fig. 3

The gene expression profile of hybrid oncocytic/chromophobe renal tumors is intermediate between that of renal oncocytoma and chromophobe renal cell carcinoma. a Principal component analysis (PCA) of gene expression for hybrid oncocytic/chromophobe renal tumors, renal oncocytomas, and chromophobe renal cell carcinomas shows the three renal cell tumor subtypes as a continuum in which three separate clusters are visualized. Hybrid oncocytic/chromophobe renal tumors are intermediate between renal oncocytomas and chromophobe renal cell carcinomas. b and c Genes with significantly different expression assessed by the fold change (fc) between renal oncocytoma and hybrid oncocytic/chromophobe renal tumor b and between chromophobe renal cell carcinoma and hybrid oncocytic/chromophobe renal tumor c. Red, blue, and yellow bars indicate statistically significant differences in gene expression (p < 0.05). Gray bars indicate genes with non-significant differences in gene expression p > 0.05