Fig. 2 | Modern Pathology

Fig. 2

From: PAX8–GLIS3 gene fusion is a pathognomonic genetic alteration of hyalinizing trabecular tumors of the thyroid

Fig. 2

Representative micrographs of hyalinizing trabecular tumors of the thyroid. A 3-mm large well-circumscribed hyalinizing trabecular tumor (a) showing tumor cells arranged in trabeculae and small nests with abundant intratrabecular hyaline material (b), and another classical case of hyalinizing trabecular tumor (c) showing elongated and spindle cells with nuclear palisading and hyaline material in the background displaying the unique cell membrane reactivity with the MIB1 monoclonal antibody against Ki67 (d)

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