Table 2 Distribution of selected histologic findings according to biochemical classifications
Histologic feature | All cases | Biochemical presentation | P value | ||
|---|---|---|---|---|---|
Hepatocellular | Mixed | Cholestatic | |||
(n = 88) | (n = 52) | (n = 18) | (n = 18) | ||
Confluent necrosis score, median | 1 (0,4) | 2.5 (0,4) | 0 (0,1) | 0 (0,2) | 0.001 |
Bridging necrosis score, median | 0 (0,1) | 0 (0,1) | 0 (0,0.25) | 0 (0,0) | 0.018 |
Interface hepatitis score, median | 1 (0,2) | 2 (1,2) | 0 (0,1) | 0 (0,2) | <0.001 |
Chronic portal inflammation score, median | 1 (0,2) | 1 (0,2) | 1 (0,2.25) | 2 (0,3) | 0.804 |
Eosinophils (N, %) | 49 (56) | 38 (73) | 6 (33) | 5 (28) | <0.001 |
Degree of necrosis seen | 0.001 | ||||
None (N, %) | 3 (3) | 0 (0) | 1 (6) | 2 (11) | |
<5% (N, %) | 17 (19) | 3 (6) | 7 (39) | 7 (39) | |
5–33% (N, %) | 33 (38) | 22 (42) | 7 (39) | 4 (22) | |
33–67% (N, %) | 33 (38) | 26 (50) | 2 (11) | 5 (28) | |
>67% (N, %) | 2 (2) | 1 (2) | 1 (6) | 0 (0) | |
Fibrosis stage, median | 1 (0,2) | 1 (0,2) | 0.5 (0,2) | 1 (0,2.25) | 0.345 |
Cholestasis grade, median | 0 (0,1) | 0 (0,1) | 0 (0,1.5) | 1 (0,3) | 0.101 |
Hepatocellular cholestasis (N, %) | 24 (27) | 9 (17) | 5 (28) | 10 (56) | 0.307 |
Canalicular cholestasis (N, %) | 25 (28) | 13 (25) | 4 (22) | 8 (44) | 0.060 |
Duct injury (multiple ducts) (N, %) | 14 (16) | 3 (6) | 5 (28) | 6 (33) | 0.480 |
Ductal paucity seen | 0.001 | ||||
None (N, %) | 74 (84) | 49 (94) | 15 (83) | 10 (56) | |
Mild (N, %) | 7 (8) | 2 (4) | 0 (0) | 5 (28) | |
Moderate to marked (N, %) | 7 (8) | 1 (2) | 3 (17) | 3 (17) | |
Ductular reaction seen (N, %) | 71 (81) | 48 (92) | 12 (67) | 11 (61) | 0.003 |
