Fig. 1 | Modern Pathology

Fig. 1

From: A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation

Fig. 1

Typical case of FET-TFCP2 rhabdomyosarcoma. MR image demonstrating an expansive and destructive mass of the occipital bone in a 31yo male (a, TFCP2-9). The proliferation was arranged in solid sheets (b) and fascicles (c). Tumor cells displayed middle-sized nuclei with distinct nucleoli and mild anisocaryosis along with abundant eosinophilic cytoplasm (d). Cells stained focally for Myogenin (e), diffusely for MYOD1 (f), and diffusely for ALK (g). Cytokeratins AE1/3 and Desmin were heterogeneously and diffusely expressed, respectively (not shown)

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