Fig. 2 | Modern Pathology

Fig. 2

From: A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation

Fig. 2

Morphological variants seen in FET-TFCP2 rhabdomyosarcomas. Three FET-TFCP2 cases displayed pure epithelioid cytomorphology where tumor cells are arranged in solid sheets (a, case TFCP2-2) and harbored abundant globoid eosinophilic cytoplasm (b). One case of FET-TFCP2 rhabdomyosarcoma (TFCP2-8) displayed more abundant fibrous and myxoid stromal changes than seen in other cases (c) and tumor cells displayed small to medium rounded nuclei with fine chromatin without nucleoli (d). This tumor was associated with a FUS-TFCP2 fusion and displayed otherwise similar immunophenotypic and RNA expression features to other FET-TFCP2 tumors. FET-TFCP2 rhabdomyosarcomas may focally display fibrous stromal changes (e). Tumor nuclei were mostly monomorphic while a subset of cases harbored marked anisokaryosis with variations in size and shape of the nuclei (f)

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