Fig. 3 | Modern Pathology

Fig. 3

From: A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation

Fig. 3

Case of FET-TFCP2 rhabdomyosarcoma with pure spindle cell moprhology. CT of an osteolytic lesion of the mandible with cortical destruction and soft-tissue extension (a, TFCP2-10). Tumor cells were arranged in intersecting fascicles with abundant eosinophilic cytoplasm (b, c). Tumor cells expressed heterogeneously desmin (d) and diffusely MYOD1 (e). Tumors cells displayed a split signal by FISH with the TFCP2 break-apart probe (f)

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