Fig. 3
From: Molecular characterization of localized pleural mesothelioma
Localized pleural mesothelioma with trisomies of chromosomes 3, 5, 7, and X (Case 4). a A scanning photomicrograph demonstrated a circumscribed solitary tumor (hematoxylin and eosin). b The tumor showed epithelioid histology, characterized by a tubular and nested pattern (100×) and c occasional vacuoles (400×). Tumor cells demonstrated calretinin (d) and WT1 (e) immunoreactivity. Mucicarmine stains, without (f) and with (g) hyaluronidase treatment, confirmed the presence of hyaluronic acid. h Single nucleotide polymorphism array analysis showed select gains of chromosomes 3, 5, 7, and X (arrows), with karyotypic analysis (i) confirming trisomies of chromosomes 3, 5, 7, and X (arrows)
