Fig. 4
From: Molecular characterization of localized pleural mesothelioma
BAP1-wild-type TRAF7-wild-type localized pleural mesothelioma with genomic near-haploidization sparing chromosomes 5 and 7 (Case 5). a A low power image (hematoxylin and eosin, 40×) demonstrated a circumscribed pleural mass adjacent to the lung. Histologically, tumor cells showed both epithelioid component (b), characterized by epithelioid cells in a tubular and solid pattern, and sarcomatoid component (c), with intermixed hyperchromatic spindle tumor cells and chronic inflammation (400×). Tumor cells demonstrated diffuse calretinin (d), patchy WT1 (predominantly in a nucleolar pattern) (e), and patchy D2-40 (f) immunoreactivity. g Copy number VisCap plot and h a plot of variant allele fraction in the targeted genome demonstrated extensive loss of heterozygosity in all chromosomes except 5 and 7 (arrows)
