Table 3 Ductal carcinoma in situ characteristics according to TILs
From: Ductal carcinoma in situ of the breast: immune cell composition according to subtype
Overall TILs in ductal carcinoma in situ | P-value univariate analysis | P-value multivariate analysis | ||
|---|---|---|---|---|
TILs low (n = 342) | TILs high (n = 131) | |||
Age at diagnosis (years) | 0.366 | 0.660 | ||
- Median (range) | 58.00 (29.00–84.00) | 57.00 (25.00–82.00) | ||
Surgery | 0.032 | 0.513 | ||
- Breast-conserving therapy | 222 (76) | 71 (24) | ||
- Mastectomy | 120 (67) | 60 (33) | ||
Diameter (missing n = 53) (in cm) | <0.0001 | 0.044 | ||
- Median (range) | 1.65 (0.1–23.0) | 2.90 (0.1–16.0) | ||
Growth pattern (%) | 0.006 | 0.350 | ||
- Solid | 160 (67) | 79 (33) | ||
- Cribriform | 153 (81) | 37 (19) | ||
- Micropapillary | 23 (62) | 14 (38) | ||
- Papillary | 6 (86) | 1 (14) | ||
Grade (%) | <0.0001 | <0.0001 | ||
- Low (G1) | 60 (90) | 3 (5) | ||
- Intermediate (G2) | 149 (90) | 17 (10) | ||
- High (G3) | 133 (55) | 111 (45) | ||
Calcification (%) | 0.105 | 0.796 | ||
- Absent | 104 (78) | 30 (22) | ||
- Present | 238 (70) | 101 (30) | ||
Comedonecrosis (%) | <0.0001 | 0.208 | ||
- Absent | 191 (82) | 43 (18) | ||
- Present | 151 (63) | 88 (37) | ||
Immunohistochemical subtype (missing n = 31) (%) | <0.0001 | <0.0001 | ||
- ER+PR±HER2− | 226 (89) | 29 (11) | ||
- ER+PR±HER2+ | 49 (61) | 31 (39) | ||
- ER−PR−HER2+ | 33 (39) | 52 (61) | ||
- ER−PR−HER2− | 8 (36) | 14 (64) | ||
Ipsilateral recurrence | 0.338 | 0.175 | ||
- No | 330 (73) | 120 (27) | ||
- Yes | 10 (63) | 6 (38) | ||
