Table 1 Demographic and pathologic data
From: Malignant mesothelioma in situ: morphologic features and clinical outcome
Case | Age/sex | History | Other biopsy features besides BAP1 loss in flat mesothelium | MTAP in biopsy | CDKN2A In biopsy | Interval from first biopsy to invasive mesothelioma | Findings in invasive mesothelioma |
|---|---|---|---|---|---|---|---|
1 | 70 F | Recurrent effusions Pleura visually normal ×2 | Partial loss | Deleted | 36 months | No data on BAP1 or CDKN2A | |
2 | 71 F | Recurrent effusions Smooth pleural thickening on CT | Not lost | Not done | 64 months | BAP1 lost, CDKN2A not deleted | |
3 | 72 F | Recurrent effusions Smooth pleural thickening on CT | Not lost | Not deleted | 92 months | BAP1 lost, CDKN2A not deleted | |
4 | 68 M | Recurrent pleural effusions | Not lost | Not deleted | 58 months | BAP1 lost, CDKN2A not deleted | |
5 | 69 M | Recurrent pleural effusions | Not done | Not deleted | 69 months | BAP1 lost, CDKN2A not deleted | |
6 | 79 M | Recurrent effusions no pleural thickening on CT/PET negative | Not done | Not done | 60 months | No data on BAP1 or CDKN2A | |
7 | 67 M | Lung cancer resection no effusion | Incidentally discovered microscopic papillary proliferation on pleural surface | Partial loss in flat mesothelium and loss in papillary areas | Not deleted | No evidence of mesothelioma at 12 months | Not applicable |
8 | 68 M | Recurrent effusions since 2008. No pleural tumor on imaging or direct visualization, but a small nodule on top of a pleural plaque biopsied | Few mm nodule of proliferating mesothelial cells (BAP1 lost in nodule) | Not lost | Not deleted | No evidence of mesothelioma at 120 months, but persisting pleural effusions. Last effusion 2017 | Not applicable |
9 | 76 M | Lung cancer resection. No pleural effusion | Incidental finding of a few mm nodule on pleural surface (BAP1 lost in nodule) | Not lost in nodule; insufficient tissue to evaluate MTAP in flat mesothelium | Not deleted | No evidence of mesothelioma at 57 months but has developed recurrent effusions | Not applicable |
10 | 53 F | Ascites. No tumor on imaging | Fibrotic scars underlying a single layer of mesothelial cells | Partial loss | Not deleted | 12 months | No data on BAP1 or CDKN2A |
