Fig. 7
IA optimization of positivity thresholds for tumor cells. In panels d and e, the points of the plotline falling on the diagonal line indicate a perfect match of the pathologist and IA scores. The red lines/regions indicate regions of increasing discordance between both ratings in 25% (absolute value) increments (e.g., the white region indicates a region where both ratings agree by ±25% and the light red region is where both ratings agree by ±50%, etc.). In panel f (after optimization), the skewness is removed (perhaps, however, at the cost of slightly inferior overall accuracy)
