Table 1 Conjunctival disease morphology. A summary of clinical details for all cases

From: Human papillomavirus type 16 causes a defined subset of conjunctival in situ squamous cell carcinomas

Case

Gender and age

Atopic history

Eye affected at primary presentation

Precise location in conjunctiva

Clinical appearance of tumour

Primary treatment modality

Resistance to primary treatment

Number of recurrences

In situ squamous cell carcinoma

1

51F

Asthma

L

Superior medial tarsus and superior medial fornix

Papillomatous

C + IF

Yes. Disease progression on treatment

3

2

60M

Asthma and eczema

BIL

Left and right: Inferior bulbar

Left and right: Red gelatinous

MMC + IF

Yes disease progression on treatment

0

3

58M

Asthma

R

Inferior bulbar

Red gelatinous

C + MMC

Yes. Persistent stable primary disease

0

4

53F

Eczema

R

Inferior bulbar and inferior tarsal

Red gelatinous nodule and gelatinous diffuse

C + 5FU

Yes

1

5

57M

Eczema

R

Inferonasal cornea

White partly translucent sheet

EX + IF

No

2

6

57F

Eczema

R

Inferior bulbar, inferior fornix and inferior plica and cornea

Red gelatinous

EX + MMC

No

1

7

49F

Eczema and asthma

BIL

Left: medial bulbar, caruncle and plica

Right: inferior medial fornix and lower medial tarsus

Left: red gelatinous nodular.

Right: red gelatinous

EX + MMC

No

2

8

76F

Eczema

R

Superior lid tarsal

Papillomatous

EX + C + MMC

Yes. Persistent stable primary disease

0

9

47M

Eczema

R

Medial limbus and bulbar

Papillomatous

Excision, MMC

Yes. Disease progression on treatment

1

10

47M

Eczema

R

Medial limbus

Papillomatous

MMC

Yes

1

11

68M

Asthma and eczema

R

Inferior cornea, bulbar, fornix and tarsus

Red gelatinous

MMC

Yes. Persistent stable primary disease

1

12

67M

Eczema

L

Medial bulbar, limbal, inferior fornix, inferomedial tarsus and caruncle

Red gelatinous mostly and papillary.

C + IF

Yes. Disease progression on treatment

1

13

45F

Eczema

L

Inferior bulbar, fornix and tarsus

Red gelatinous and leukoplakic

IF

No

1

14

59F

Asthma and czema

BIL

Left and right: Inferior bulbar, fornix and tarsus

Left and right: Leukoplakic

MMC

Yes. Persistent stable primary disease

1

15

50M

Asthma and eczema

BIL

Left: Medial bulbar

Right: Inferior medial bulbar

Left: red gelatinous

Right: leukoplakic

MMC

No

0

16

57F

Asthma and eczema

R

Medial limbus, inferonasal bulbar and inferior fornix

Leukoplakic

C + MMC

No

1

17

52F

None

BIL

Left: Medial bulbar, plica

Right: inferomedial bulbar, medial inferior fornix

Left: red nodular

Right: red nodular

MMC

No

2

18

87M

None

L

Medial and temporal limbus

Red gelatinous

C + MMC

No

2

19

103M

Non

R

Medial limbus

Leukoplakic

EX + C

No

0

20

82M

None

R

Medial limbus

Leukoplakic

EX + C

No

0

21

94M

None

R

Inferior fornix

Red gelatinous

EC + MMC

No

0

22

36M

None

R

Medial limbus

Leukoplakic

EX + C

No

0

23

71M

None

R

Superonasal limbus and cornea

papillomatous

MMC

No

0

24

94M

None

R

Lateral cornea, lateral limbus

Leukoplakic

MMC

No

1

25

81M

None

R

Medial limbus and medial bulbar

Red gelatinous nodule

MMC

No

0

26

88M

None

L

Left inferior limbus and left inferonasal cornea

White translucent sheet over cornea and leukoplakic patch inferior limbus

EX + MMC

No

0

27

78F

None

L

Medial limbus

Gelatinous

EX + C

No

0

28

87M

None

R

Medial limbus

red gelatinous and leukoplakic

Excision

No

0

29

88M

None

R

Medial limbus and medial cornea

Leukoplakic

MMC

No

0

30

58M

None

R

Medial limbus and medial cornea

Leukoplakic

EX + C + AL

No

0

31

51F

Non

L

Inferomedial bulbar and inferior medial fornix

Leukoplakic

MMC

No

1

Dysplasia

32

81F

None

L

Sueronasal bulbar and cornea

Papillomatous

EX + C + MMC

No

1

33

79F

None

R

Inferior fornix

red nodular

EX + MMC

No

0

34

53F

Eczema and allergic conjunctivitis

L

Lower lateral tarsal

Red nodular

MMC

No

1

35

21F

None

L

Lateral limbus

Leukoplakic

EX + C

No

0

36

55F

None

L

Inferior fornix

Leukoplakic

EX + C

No

0

37

78M

None

R

Medial fornix

Leukoplakic

EX + C

No

0

38

74M

Eczema

L

Caruncle and plica

Leukoplakic

EX + C

No

0

39

61M

None

R

Temporal limbus

Red gelatinous nodule

EX + C

No

0

40

76M

None

R

Nasal limbus

Leukoplakic

IF

No

0

41

65M

None

R

Inferomedial fornix

Leukoplakic

C

No

1

  1. Cases 1−31 are those with a histological diagnosis of conjunctival in situ squamous cell carcinoma. Cases 1−16 represent patients with atopy (asthma, eczema) and cases 17−31 are the non-atope group. Cases 32−41 are those with a histological diagnosis of conjunctival mild or moderate conjunctival epithelial dysplasia
  2. L left, R right, BIL bilateral, C cryotherapy, IF intralesional interferon, MMC Mitomycin C, 5FU 5-Fluorouracil, EX excision, AL alcohol