Table 2 Next generation sequencing findings of FLT3-tyrosine kinase domain mutations in cases positive for D835/I836 mutations by fragment analysis

From: Hybridization capture-based next generation sequencing reliably detects FLT3 mutations and classifies FLT3-internal tandem duplication allelic ratio in acute myeloid leukemia: a comparative study to standard fragment analysis

Fragment analysis results

Next generation sequencing results

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2504 A>T; p.D835V

Positive D835/I836 substitution

c.2503 G>C; p.D835H

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2503 G>A; p.D835N;

c.2504 A>T; p.D835V;

c.2028 C>T; p.N676K

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2503 G>T; p.D835Y

Positive D835/I836 substitution

c.2503 G>C; p.D835H;

and internal tandem duplication

c.1827_1828ins90; p.L610_E611ins30

Positive D835/I836 substitution

c.2503 G>T; p.D835Y;

and internal tandem duplication

c.1759_1788dup; p.N587_E596dup

Positive D835/I836 3 bp deletion

c.2508_2510del; p.I836del;

and internal tandem duplication

c.1754_1795dup; p.S585_E598dup

Positive D835/I836 6 bp deletion

c.2500_2505del; p.R834_D835del;

and internal tandem duplication

c.1744_1830dup; p.T582_L610dup

Positive D835/I836 6 bp deletion

c.2500_2505del; p.R834_D835del;

and internal tandem duplication

c.1744_1830dup; p.T582_L610dup

Positive D835/I836 substitution

c.2503 G>T; p.D835Y;

and internal tandem duplication

c.1786_1806dup; p.E596_K602dup

Positive D835/I836 substitution

c.2503 G>T; p.D835Y;

and internal tandem duplication

c.1743_1802dup; p.T582_L601dup

Positive D835/I836 substitution

c.2504 A>T; p.D835V;

and internal tandem duplication

c.1837_1837 + 1ins57; p.F612_G613ins19

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