Fig. 5 | Modern Pathology

Fig. 5

From: KSHV/HHV8-positive large B-cell lymphomas and associated diseases: a heterogeneous group of lymphoproliferative processes with significant clinicopathological overlap

Fig. 5

HHV8-positive diffuse large B-cell lymphoma, not otherwise specified. a–c Lymph node involved by a lymphoma with a vaguely nodular pattern. The tumor cells are large immunoblasts. d–h They are variable positive for d CD20, and negative for e CD138. The tumor cells are positive for f CD30, g LANA-1, and h EBER. This case was difficult to classify but the diagnosis of HHV8-positive diffuse large B-cell lymphoma was favored because of the presence of multiple lymphadenopathies, expression of cytoplasmic IgM, and negativity for CD138 in the absence of pathologic findings of multicentric Castleman disease or germinotropic lymphoproliferative disorder

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