Table 2 Typical immunophenotype of HHV8+ plasmablasts in PEL, MCD, DLBCL, and GLPD

From: KSHV/HHV8-positive large B-cell lymphomas and associated diseases: a heterogeneous group of lymphoproliferative processes with significant clinicopathological overlap

 

CD45/LCA

Pan B-cell markers

Plasma cell markers

IgM

Igs

EBER

Other

PELa

+

CD19−, CD20−, CD79a−, PAX-5-

CD138+, CD38+, MUM1+,

−

−

+

CD30+, PD-L1+ CD3+/−

MCD

+

CD19+, CD20−, PAX-5−, CD79a−

CD138-, CD38+, MUM1+

+

+ (λ)

−

 

DLBCL

+/−

CD19+/−, CD20+/−, CD79a-

CD138-, CD38-, MUM1+,

+

+

−

 

GLPD

−

CD19−, CD20−, CD79a-, PAX-5-

CD138-/+, CD38+/−, MUM1+

+/−

+

+

vIL-6+, IgA+, CD30-, CD3+ partial, PD-L1+

  1. +/− Occasional cases reported positive
  2. aSolid PEL expresses pan B-cell markers and Igs more often than classic PEL. CD45/LCA is positive in 75% in solid PEL and 95% in classic PEL
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