Table 3 Differential diagnosis of HHV8 lymphoproliferative disorders presenting as solid masses (typical features)

From: KSHV/HHV8-positive large B-cell lymphomas and associated diseases: a heterogeneous group of lymphoproliferative processes with significant clinicopathological overlap

 

Location

HIV

EBER

Somatic mutations of the IGH

Monoclonality (IGH)

Solid PEL

Extranodal

Positive

Positive

Yes

Yes

HHV8 MCD

Nodal

Positive

Negative

No

No

HHV8 DLBCL

Nodal or extranodal

Positive

Negative

No

Yes

HHV9 GLPD

Nodal

Negative

Positive

Yes

No

  1. MCD multicentric Castleman disease, DLBCL diffuse large B-cell lymphoma and GLPD, germinotropic lymphoproliferative disorder