Fig. 1 | Modern Pathology

Fig. 1

From: Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies

Fig. 1

Surface Plasmon Resonance analysis of r22C3 and r28-8 antibodies to PD-L1 protein. a Surface Plasmon Resonance response of PD-L1 binding to 90 RU of r22C3 antibody captured on an anti-mouse IgG functionalized C1 sensor chip. b Saturation of r22C3 antibody with PD-L1 extracellular domain followed by injection of a dilution series of r28-8 antibody over the r22C3-PD-L1 complex, resulting in additional increase in response. Ig immunoglobulin, PD-L1 programmed cell death ligand-1, r22C3 recombinant 22C3, r28-8 recombinant 28-8, RU resonance units

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