Fig. 2

Hepatic lesion of patient 1 demonstrates areas consistent with a hepatocellular adenoma (H&E, 10×) and b well-differentiated hepatocellular carcinoma; note absence of steatosis in the malignant component (H&E, 10×). c Preserved reticulin framework despite macrovesicular steatosis is noted in the hepatocellular adenoma component (reticulin, 10×), meanwhile d disrupted reticulin framework with associated thickened trabeculae is seen in the area of hepatocellular carcinoma (reticulin, 10×). Liver fatty acid binding protein is not expressed in the e hepatocellular adenoma (liver fatty acid binding protein, 10×) and f hepatocellular carcinoma component (liver fatty acid binding protein, 10×). Inset e highlights normal expression of liver fatty acid binding protein in the adjacent nonneoplastic liver tissue (liver fatty acid binding protein, 10×)