Table 3 Comparison between patients with liver fatty acid binding protein-deficient hepatocellular adenoma and β-catenin mutated hepatocellular adenoma showing malignant transformation

From: Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon

Characteristics

LFABP-deficient hepatocellular adenomas

β-catenin mutated hepatocellular adenomasa [12,13,14,15,16,17,18,19,20,21,22]

P value

Number of patients

13

30

 

Number of female

10 (77%)

10 (33%)

0.018

Mean age (range; years)

46 (18–75)

44 (20–66)

0.52

Risk factors

BCS, MODY type 3, DM

Androgen/steroid, OCP, GSD type 1

 

Multiple adenomas

10 (77%)

3 (16%)

0.0009

Lesion size (range; cm)

4–15.5

2–34

0.15

HCC grade

Well-differentiated (100%)

Well-differentiated (67%), moderately-differentiated (27%), poorly differentiated (6%)

 

Others

5 cases with adenomatosis background (39%)

4 cases from primary authors institution; 26 cases from the literature

 
  1. HCC hepatocellular carcinoma, LFABP liver fatty acid binding protein, BCS Budd–Chiari syndrome, MODY maturity-onset diabetes of the young, DM diabetes mellitus, OCP oral contraceptive pills, GSD glycogen storage disease
  2. aβ-catenin mutated hepatocellular adenoma cases included 4 cases from primary authors’ institution and 26 cases from the literature [12,13,14,15,16,17,18,19,20,21,22] (see Supplementary Table 1 for details)
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