Table 1 Core agreement status by level of core variability and PD-L1 status for 1, 25, and 50% cutoffs

From: Programmed death-ligand 1 expression influenced by tissue sample size. Scoring based on tissue microarrays’ and cross-validation with resections, in patients with, stage I–III, non-small cell lung carcinoma of the European Thoracic Oncology Platform Lungscape cohort

Overall TMA PD-L1 score

One core onlya (n = 284)

Concordant cases

Discordant cases

All cases with available TMA PD-L1 result

Number of available cores

Totalb

Twoa (n = 330)

Threea (n = 398)

Foura (n = 996)

Cutoff 1%

  <1%

169 (59.5)

169 (51.2)

222 (55.8)

504 (50.6)

895 (92.8%)

69

1133

  ≥1%

115 (40.5)

130 (39.4)

117 (29.4)

289 (29.0)

536 (70.5%)

224

875

 Total

284 (100.0)

299 (90.6)

339 (85.2)

793 (79.6)

1431 (83.0%)

293

2008

Cutoff 25%

  <25%

208 (73.2)

240 (72.7)

295 (74.1)

715 (71.8)

1250 (93.3%)

86

1547

  ≥25%

76 (26.8)

73 (21.1)

58 (14.6)

156 (15.7)

287 (74.5%)

101

461

 Total

284 (100.0)

313 (94.8)

353 (88.7)

871 (87.4)

1537 (89.1%)

187

2008

Cutoff 50%

  <50%

230 (81.0)

259 (78.5)

315 (79.1)

784 (78.7)

1358 (94.4%)

80

1668

  ≥50%

54 (19.0)

54 (16.4)

46 (11.6)

120 (12.1)

220 (76.9%)

66

340

 Total

284 (100.0)

313 (94.8)

361 (90.7)

904 (90.8)

1578 (91.5%)

146

2008

  1. Single-core cases are not included in the estimation of concordance
  2. aPercentages (%) are calculated over the total number of cases per column
  3. bPercentages (%) are calculated over the total number of cases per row, excluding single-core cases
  4. Bold numbers represent the % of concordant cases in each one of the three thresholds considered for analysis
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