Fig. 2

Histopathology of Spitz Nevi with MAP3K8 fusion. a, b Symmetrical, well-circumscribed, mainly junctional Spitz nevi. c Close-up view of a with vertically oriented nests of small spindled and pigmented melanocytes with hyperplastic epidermis. d Close-up view of b with vertically oriented nests of large spindled melanocytes below a hyperplastic epidermis and smaller, pigmented nevoid cells at the bottom. e Exophytic Spitz nevus with nests of spindled and epithelioid melanocytes with hyperplastic epidermis. f Close-up view of e. Pagetoid scatter and epithelioid and small clusters of spindled and epithelioid melanocytes in the upper dermis