Fig. 6

Malignant Spitz tumor with MAP3K8 fusion (same case as Fig. 1b). a Dome-shaped, mainly dermal proliferation with deep invasion of the subcutis. b Confluent dermal nests underneath a normal appearing epidermis. The Grenz zone is not obscured. Nests are enveloped by fibrous septa with inflammatory cells. c Close-up view of nests with dense aggregates of spindled and epithelioid, unpigmented melanocytes. A mitotic figure is visible at the left. d Array comparative genomic hybridization profile with losses of several chromosomal regions and gain of chromosome 15