Fig. 7
From: Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations
Molecular findings. a Frequency plot chromosomal aberrations as determined by array comparative genomic hybridization. Gains are shown in red and losses in green. b Graphical view of two MAP3K8-SVIL fusions involving with a breakpoint either before exon 4 or 6 of SVIL. c Box-plot expression levels of MAP3K8 from RNAseq data in MAP3K8-fused and tyrosine kinase-fused Spitz tumors. d MAP3K8 FISH break-apart probe showing disruption of one of the signal pairs (arrows) with loss of one green signal Insert showing mapping of FISH probes (Case no. 10 with MAP3K8-SVIL fusion)
