Table 1 Clinical data
From: Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations
MAP3K8 fusion | Spitz nevus | Atypical Spitz tumor | Malignant Spitz tumor | MAP3K8-SVIL Fusion | |
|---|---|---|---|---|---|
n | 33 | 5 | 13 | 15 | 13 |
Sex M/F | 15/18 | 1/4 | 7/6 | 7/8 | 7/6 |
Age range (median) | 2–59 (18) | 2–45 (23) | 2–45 (18) | 5–59 (13) | 11–45 (30) |
Topography | |||||
Head | 5/33 | 0 | 3 | 2/14 | 0/15 |
Trunk | 4/33 | 0 | 0 | 4/14 | 3/15 |
Upper limb | 6/33 | 0 | 4 | 2/14 | 2/15 |
Lower limb | 18/33 | 5 | 7 | 6/14 | 8/15 |
Diameter | 2–35 (6) | 2–6 (4.5) | 3.5–8.5 (6) | 4.5–27 (7) | 3.5–14 (6) |
Follow-up in months (n = 26) | 3–96 (6) | 3–12 (6) | 3–18 (6) | 6–96 (9) | 6–36 (8) |
Positive SLN | 2/6 | ND | ND | 2/6 | 1/3 |
