Table 1 Recommended immunohistochemistry screening panel for challenging cutaneous epithelioid tumors
Recommended immunohistochemistry screening panel for cutaneous epithelioid tumors | ||||||
|---|---|---|---|---|---|---|
Cytokeratins | S100 or SOX10 | SMA | CD45 | CD34 | CD31 or ERG | |
Carcinoma | + | − | − | − | − | − |
Melanoma | − | + | − | − | − | − |
Lymphoma | − | − | − | + | − | − |
Epithelioid fibrous and fibrohistiocytic tumors | − | − | − | − | − | − |
Epithelioid peripheral nerve sheath tumors | − | + | − | − | − | − |
Epithelioid tumors with myoid or myoepithelial differentiation | +/− | +/− | +/− | − | − | − |
Epithelioid vascular tumors | − | − | + | − | + | + |
