Table 5 Features that distinguish cellular dermatofibroma from dermatofibrosarcoma protuberans

From: Cutaneous soft tissue tumors: how do we make sense of fibrous and “fibrohistiocytic” tumors with confusing names and similar appearances?

Cellular dermatofibroma

Dermatofibrosarcoma protuberans

Epidermal hyperplasia

No epidermal hyperplasia

Lateral hyaline collagen entrapment

Diffuse infiltration of dermis

Mixed fascicular and storiform pattern

Tight storiform pattern

Pale eosinophilic cytoplasm

Minimal cytoplasm

Superficial fat entrapment

Diffuse infiltration of fat

CD34 usually negative

CD34 positive

SMA multifocally positive

SMA negative

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