Fig. 6

Genetic classification of nevi, melanocytomas, and melanomas. A single initiating mutation is found in nevi, with different initiating mutations corresponding to different subtypes. Combinations of mutations occur in melanocytomas which often arise from pre-existing nevi. Melanomas on skin with high amounts of chronic sun-damage (high-CSD) and acral and mucosal melanomas often do not arise from a preexisting nevus