Table 2 Clinical features of the 13 early-stage pulmonary lymphoepithelioma-like carcinoma patients

From: A multicenter analysis of genomic profiles and PD-L1 expression of primary lymphoepithelioma-like carcinoma of the lung

Patient ID

Age

Gender

Smoking status, smoking pack years

Disease stage

Treatment regimen received

Best response

Immunotherapy, best response

Number of CNVs detected

TMB (mutations/Mb)

PD-L1 TPS (%)

Degree of lymphoid cell infiltration

Date of diagnosis

OS as of last follow-up date (months)

Survival status

P05

59

Male

Smoker, 20

IB

RT

SD

No

0

3.2

0

10%

2017/2/8

14.0

Alive

P17

38

Male

Smoker, 40 (10 years water pipe)

IIA

S + adj CT

SD

No

0

1.6

20

40%

2017/1/4

19.9

Alive

P22

55

Male

Smoker, 40

IIA

S + adj CT

No

0

0.8

5

40%

2018/12/1

0.1

Alive

P04

39

Male

Smoker, 10

IIB

S + adj CT

SD

No

0

0a

0

50%

2016/12/7

14.9

Alive

P08

56

Female

No

IIB

Neo CT + S + adj CT

Nivolumab, SD

7

27.8

30

20%

2017/10/2

14.2

Alive

P24

57

Female

No

IIB

S

No

0

2.4

60

10%

2018/12/13

0.2

Alive

P01

43

Male

Smoker, 1

IIIA

Neo CT + S + adj CT + RT

SD

No

0

1.6

0

40%

2015/7/1

41.4

Alive

P02

55

Female

No

IIIA

Neo CT + S + adj CT

SD

No

0

1.6

30

40%

2016/10/31

6.3

Alive

P23

48

Male

Smoker, 15

IIIA

S + adj CT

SD

No

0

1.6

2

40%

2015/7/26

39.9

Alive

P14

58

Female

No

IIIA

S + adj CT

SD

No

2

3.2

2

40%

2015/8/7

37.2

Alive

P20

64

Male

Smoker, 10

IIIA

CT

PR

No

7

4

0

30%

2018/4/17

7.5

Alive

P27

64

Female

No

IIIA

CT

No

0

3.2

20

50%

2018/11/23

0.9

Alive

P15

47

Female

No

IIIA

CT

PR

No

2

0.8

50

5%

2016/9/15

27.4

Alive

  1. – Data not available
  2. Adj CT adjuvant chemotherapy, CNV copy number variation, CT chemotherapy, Neo CT neoadjuvant chemotherapy, OS overall survival, PR partial response, RF relapse-free, RT radiotherapy, S surgery, SD stable disease, TMB tumor mutation burden, TPS tumor positive score
  3. aPatient P04 was wild-type in all the genes in the panel used