Fig. 5
From: Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together
Primary cutaneous γδ T-cell lymphoma. a The typical clinical presentation of this lymphoma is that of rapidly growing hemorrhagic ulcerated tumor nodules. Histopathologically, involvement of the dermis and subcutaneous adipose tissue is observed. b In contrast, predominantly epidermotropic primary cutaneous γδ T-cell lymphoma may present with lesions clinically similar to mycosis fungoides. c Histological examination of the case shown in b reveals a markedly epidermotropic infiltrate composed of atypical lymphocytes. Notice some dyskeratotic keratinocytes and hemorrhage, indicative of cytotoxicity (H&E, ×200). d. The atypical lymphocytes are positive for TCRγ, in contrast to the scattered reactive lymphocytes seen in the superficial dermis (immunoperoxidase, ×100)
