Fig. 5 | Modern Pathology

Fig. 5

From: DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma

Fig. 5

Schematic representations of PRKACA fusions detected by the MSK-Fusion targeted RNASeq assay. a DNAJB1-PRKACA in-frame fusion resulting from a 400 Kb deletion on chromosome 19 and joining exon1 of DNAJB1 (NM_006145) to exons 2–10 of PRKACA (NM_002730). b ATP1B1-PRKACA fusion derived from a translocation between chromosome 1 and chromosome 19. This in-frame fusion event involves exon 1 of ATP1B1 (NM_001677) and exons 2–10 of PRKACA (NM_002730). The chimeric transcript sequence and its corresponding protein sequence are indicated under the fusion breakpoint region. +/− indicate the direction of transcription of each gene

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