Table 1 Clinicopathologic Features of the Pancreatobiliary Neoplasms with PRKACA Fusions
Case | Age /Sex | Initial presentation | Pathology diagnosis | Clinical follow-up | ||
|---|---|---|---|---|---|---|
Intraductal component | Invasive component | Metastasis | ||||
1 | 63/M | 7 cm mass in head of the pancreas | IOPN | Invasive adenocarcinoma with mucinous and oncocytic features | Not applicable | No follow-up data available |
2 | 47/M | 10 cm cystic mass in caudate lobe of liver | IOPN of the bile ducts | Invasive adenocarcinoma with oncocytic features | Not applicable | Recurrence after 4 years; now deceased |
3 | 36/M | 4.5 cm cystic mass in head of the pancreas | IOPN | Not applicable | Not applicable | No evidence of disease for 10 years |
4 | 58/F | Complex cystic mass in head of the pancreas | IPMN, mixed oncocytic and pancreatobiliary features | Minute focus of invasion with mucinous and oncocytic features | Not applicable | No adjuvant therapy given. No evidence of disease for 9 months |
5 | 52/M | 2.8 cm cystic mass in head of the pancreas | IPMN, mixed oncocytic and gastric features | Not applicable | Not applicable | No evidence of disease for 6 years |
6 | 76/M | Distal pancreatic mass | IPMN, mixed oncocytic and pancreatobiliary features | Invasive adenocarcinoma | Metastatic adenocarcinoma with oncocytic features, involving liver | Recurrence and liver metastases after 20 years, disease progression despite chemotherapy |
