Table 3 Characteristics of primary IPMNs and recurrent tumors

From: Metachronous intraductal papillary mucinous neoplasms disseminate via the pancreatic duct following resection

Patient

Primary IPMN

Recurrent lesion

Estimated distance between primary and recurrent lesion (mm)

Epithelial type

KRAS

GNAS

Other mutations

Immunohistochemistrya p53/SMAD4/p16/β-catenin

Surgical margin (dPCR)

Epithelial type

KRAS

GNAS

Other mutations

Immunohistochemistrya p53/SMAD4/p16/β-catenin

 

1

I

WT

R201C

RNF43 D300Y

0/0/1/0

ND

I

WT

R201C

RNF43 D300Y

0/1/1/0

Unknown

2

G

G12D

WT

STK11 E199X

0/2/0/0

ND

G

G12D

WT

STK11 E199X

0/2/0/0

25

3

PB

G12D

WT

–

0/1/0/0

KRAS G12D

GNAS R201Hb

PB

G12D

WT

–

0/1/0/0

<5

4

I

G12V

R201H

–

0/0/0/1

ND

I

G12V

R201H

–

0/0/0/0

10

5

G

G12V

R201C

–

0/0/0/0

KRAS G12V

GNAS R201C

I

G12V

R201C

–

0/0/1/0

0

6

PB

G12V

WT

CTNNB1 S33P

CTNNB1 S45delc

STK11 Y60delc

STK11 E33X

0/1/1/1

ND

PB

G12V

WT

CTNNB1 S33P

CTNNB1 S45delc

STK11 Y60delc

STK11 E33X

0/1/1/0

65

7

PB

G12V

WT

CTNNB1 S37Lc

0/2/0/1

ND

PB

G12V

WT

CTNNB1 S37Lc

0/2/0/1

45

8

PB

G12D

WT

CTNNB1 G34V

STK11 G196R

0/0/1/0

ND

PB

G12D

WT

STK11 G196R

0/0/1/0

15

9

I

G12V

R201H

RNF43 R371Xc

0/2/0/1

ND

–

G12D

WT

CDKN2A splicesite_5

1/2/1/0

15

  1. I intestinal, G gastric, PB pancreatobiliary, ND KRAS and GNAS mutations not detected
  2. aScoring of immunohistochemistry p53: 0, negative (weak staining); 1, strong positive SMAD4: 0, retained; 1, weak (suggestive of haploinsufficiency); 2, loss p16: 0, retained; 1, loss β-catenin: 0, membrane staining; 1, nuclear accumulation
  3. bGNAS mutation was found in low-grade dysplasia in the incipient lesion at the branch duct but not at the main pancreatic duct
  4. cCOSMIC (http://cancer.sanger.ac.uk/cosmic) and ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar/) were used to classify variants of unknown significance
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