Table 3 Multivariate analysis of tumor budding using the tumor budding scoring system proposed by the International Tumor Budding Consensus Conference (ITBCC) 2016

 Tumor budding (ITBCC)

0.015

1.710

1.111

2.632

 UICC-stage

0.470

1.105

0.843

1.448

 Sex

0.092

0.290

0.069

1.224

 Tumor size

0.024

1.018

1.002

1.033

 Resection status

0.099

1.929

0.884

4.209

 Pleural invasion

0.783

1.044

0.769

1.418

 Desmoplasia

0.602

1.246

0.544

2.855

 Tumor budding (ITBCC)

0.005

1.457

1.123

1.890

 UICC-stage

0.014

1.219

1.041

1.427

 Age

<0.001

1.049

1.024

1.073

 Sex

0.055

0.521

0.268

1.013

 Tumor size

0.318

1.005

0.995

1.015

 Resection status

0.414

1.246

0.735

2.112

 Pleural invasion

0.685

1.042

0.853

1.274

 Desmoplasia

0.375

1.233

0.776

1.958

 Tumor budding (ITBCC)

0.002

1.581

1.186

2.108

 UICC-stage

0.192

1.131

0.940

1.361

 Age

<0.001

1.059

1.031

1.089

 Sex

0.033

0.399

0.171

0.928

 Tumor size

0.036

1.012

1.001

1.023

 Resection status

0.089

1.642

0.927

2.910

 Pleural invasion

0.786

0.969

0.773

1.215