Table 1 Histologic and clinical variables in patients treated for graft-versus-host disease compared with untreated patients.
From: Evaluation of the lower histologic threshold for gastric graft versus host disease
Treated (n = 45) | Not treated (n = 18) | P value | |
|---|---|---|---|
Mean age (years) | 51.0 | 52.1 | 0.74 |
Sex (M:F) | 1.1:1 | 2.4:1 | 0.25 |
Mean time from transplant (days) | 377 | 633 | 0.24 |
Mean number of biopsy fragments | 4.2 | 3.9 | 0.51 |
>1 apoptotic body per biopsy fragment | 16/45 (36%) | 2/18 (11%) | 0.07 |
Maximum apoptotic count per 10 contiguous gastric pits | 2.1 | 0.9 | 0.01 |
Evidence of graft-versus-host disease in corresponding gastrointestinal biopsies (nongastric)a | 35/44 (80%) | 0/16 (0%) | <0.0001 |
Evidence of extraintestinal graft-versus-host disease | 27/45 (60%) | 3/18 (17%) | 0.002 |
Evidence of graft-versus-host disease in corresponding gastrointestinal biopsies and/or at extraintestinal sites | 42/45 (93%) | 3/18 (17%) | <0.0001 |
Evidence of infectiona | 10/44 (23%) | 3/18 (17%) | 0.74 |
On mycophenolate | 14/45 (31%) | 6/18 (33%) | 1.0 |
On proton pump inhibitor | 38/45 (84%) | 12/18 (67%) | 0.17 |
