Fig. 1: Morphological and immunohistochemical features of adenoid cystic carcinomas of the breast. | Modern Pathology

Fig. 1: Morphological and immunohistochemical features of adenoid cystic carcinomas of the breast.

From: Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations

Fig. 1

Conventional-type ACC with MYB rearrangement (case 8) (a–e), without MYB rearrangement (case 11) (f–j), and solid-type ACC (case 30) (k–o). Morphology (a, f, k) (hematoxylin & eosin stains) showing a cribriform growth pattern in conventional-type ACCs and a solid growth pattern in solid-type ACC. p63 immunostaining (b, g, l) is positive in the myoepithelial cells in conventional-type ACCs and negative in this solid-type ACC. MYB immunostaining (c, h, m) is strongly positive in myoepithelial cells in conventional-type ACCs and diffusely positive in this solid-type ACC. CK7 immunostaining (d, i, n) is positive in the epithelial cells of conventional-type ACCs and highlights intercalated duct-like structures embedded in the tumor islands in this solid-type ACC. NICD1 nuclear immunostaining (e, j, o) is positive in the epithelial cells of conventional-type ACCs, and diffuse in this solid-type ACCs.

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