Fig. 3: Main recurrent copy number variations of 15 cases of adenoid cystic carcinomas by array-CGH analysis. | Modern Pathology

Fig. 3: Main recurrent copy number variations of 15 cases of adenoid cystic carcinomas by array-CGH analysis.

From: Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations

Fig. 3

The main alterations involved chromosomes 12, 14, and 17. Losses are represented in blue and gains in red. On chromosome 12, minimal common area deleted in cases 1, 2, 5, 7, 8, and 29 concerned 4.1 Mb and involved 110 genes. On chromosome 14, minimal common area deleted in cases 10, 16, 18, 21, 22, 31, and 32 concerned 6.3 Mb and involved 22 genes. On chromosome 17, minimal common area deleted in cases 5, 8, 9, 29, 30 and 31, concerned 10.8 Mb and involved 291 genes. On this same chromosome, cases 5, 8, 9, 29, and 30 also had a gain. Case 29 was the only case having amplification of the CCND1 locus seen on chromosome 11.

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